Dr. Marcus Butler
Inclusion Criteria:
- Participants must have a histologically or cytologically confirmed diagnosis of
unresectable or metastatic melanoma of cutaneous, acral or mucosal subtype
- Availability of an archival tumour sample and a fresh tumour biopsy taken at
screening
- Patient must have received at least 1 prior immunotherapy (anti-PD-(L)1 ±
anti-CTLA-4 [Cytotoxic T-lymphocyte-associated protein 4]) for a minimum of 6 weeks
and no more than 2 prior regimens in the metastatic setting. Patients must have
confirmed progression during treatment with a PD-(L)1 inhibitor +/- a CTLA-4
inhibitor.
- The interval between the last dose of anti-PD-(L)1, BRAF/MEK (B-Rapidly Accelerated
Fibrosarcoma gene/mitogen-activated protein kinase gene) inhibitor and the first
dose of the study regimen must be a minimum of 14 days
- Measurable disease by RECIST 1.1.
- Patients must have a life expectancy ≥3 months from proposed first dose date.
- Biopsy Sub-study: Consent to the provision of 3 mandatory tumour biopsies.
Exclusion Criteria:
- Patients must not have experienced a toxicity that led to permanent discontinuation
of prior checkpoint inhibitors (CPI) treatment.
- History of another primary malignancy except for malignancy treated with curative
intent with no known active disease ≥ 3 years before the first dose of study
treatment
- Uveal melanoma
- Must not have experienced a Grade ≥ 3 immune-related AE or an immune-related
neurologic or ocular AE of any grade while receiving prior immunotherapy
- History of symptomatic congestive heart failure, unstable angina pectoris,
uncontrolled cardiac arrhythmia, which is symptomatic or requires treatment (CTCAE
Grade 3), symptomatic or uncontrolled atrial fibrillation despite treatment, or
asymptomatic sustained ventricular tachycardia. Patients with atrial fibrillation
controlled by medication or arrhythmias controlled by pacemakers may be permitted
upon discussion with the study clinical lead.
- History of organ transplant that requires use of immunosuppressive medications
- Inadequate bone marrow and impaired hepatic or renal function
- Known active infection requiring systemic therapy, active hepatitis infection,
positive hepatitis C virus antibody, hepatitis B virus (HBV) surface antigen or HBV
core antibody (anti-HBc), at screening
- Patients with confirmed COVID-19 infection by polymearse chain reaction test who
have not made a full recovery.