Genentech, Inc.
Dr. Adrian Sacher
Inclusion Criteria:
- Histologically documented advanced or metastatic solid tumor with KRAS G12C
mutation.
- Women of childbearing potential must agree to remain abstinent or use contraception,
and agree to refrain from donating eggs during the treatment period and after the
final dose of study treatment as specified in the protocol.
- Men who are not surgically sterile must agree to remain abstinent or use a condom,
and agreement to refrain from donating sperm during the treatment period and after
the final dose of study treatment as specified in the protocol.
Exclusion Criteria:
- Active brain metastases.
- Malabsorption or other condition that interferes with enteral absorption.
- Clinically significant cardiovascular dysfunction or liver disease.