Cancer Clinical Research Unit

Inclusion Criteria: - Histologically confirmed squamous cell carcinoma, adenocarcinoma or adenosquamous carcinoma of the cervix, FIGO stage IB-IVA - 3.1.2 Planned for radical radiotherapy and concurrent cisplatin chemotherapy. - 3.1.3 Age ≥ 18 years. Exclusion Criteria: - Evidence of distant metastases (suspicious paraaortic nodes below the renal vessels allowed if they will be encompassed within the radiation field) - Patients who have received any anticancer treatment for their cervical cancer. - Other cervical cancer tumor histologies (e.g. small cell, serous) - Contraindications to 18FDG PET-CT - Contraindication to radiotherapy (e.g. severe Crohn's disease) - Contraindication to chemotherapy (e.g. non-reversible renal failure) - History of another invasive malignancy, except for non-melanoma skin cancer or tumors curatively treated with no evidence of disease for ≥ 5 years. - Known pregnancy or lactating