​​​​Our study of unique and innovative treatment approaches has helped set the standard of care in central nervous system ​oncology. As the largest central nervous system treatment centre in Canada, we are also able to conduct cutting-edge clinical trials for specific brain tumours (for example glioblastoma, brain metastases) and in parallel investigate advances in the treatment of uncommon tumour types because we have enough patients to support such trials. 

Members of our neurosurgical and neuropathology staff perform basic research in the laboratory through the ​MacFeeters-Hamilton Neuro-Oncology Laboratory​.

Current studies include the investigation of the regulatory mechanisms underlying central nervous system tumours and exploration of the mechanisms involved in angiogenesis associated with these tumours, as well as genome-driven molecular diagnostic precision oncology.

Open Clinical Trials

 
NCT and Other Names
 
Title
 
Principal Investigator
 
Disease Location
Glioblastoma Multiforme
NCT03970447
GCAR-7213
A Trial to Evaluate Multiple Regimens in Newly Diagnosed and Recurrent GlioblastomaDr. Warren MasonGlioblastoma Multiforme
Multiple Sites
NCT04962672
21-5527.0
Anesthesia Induced Brain Cancer Survival (ABC Survival): A Feasibility StudyDr. Tumul ChowdhuryMultiple Sites
NCT04940507
20-6243, 707126
BRAINFUL (BRAIN Tumor Focused Ultrasound-enabled Liquid Biopsy) TrialDr. Andres LozanoMultiple Sites
NCT03606421
18-5106
CBF and NCF Changes With Brain RadiationDr. David ShultzMultiple Sites
NCT04244019
19-6056
FLT-PET / MRI Brain MetsDr. David ShultzMultiple Sites
NCT03550391
CCTG CE.7, NCI-2018-00395
Stereotactic Radiosurgery Compared With Hippocampal-Avoidant Whole Brain Radiotherapy (HA-WBRT) Plus Memantine for 5 or More Brain MetastasesDr. David ShultzMultiple Sites
Other
NCT03180268
NRG-BN003, NCI-2016-01619,NRG-BN003,NRG-BN003,NRG-BN003,U10CA180868
Observation or Radiation Therapy in Treating Patients With Newly Diagnosed Grade II Meningioma That Has Been Completely Removed by SurgeryDr. Derek TsangOther
NCT05580562
ONC201-108
ONC201 in H3 K27M-mutant Diffuse Glioma Following Radiotherapy (the ACTION Study)Dr. Julie BennettOther
NCT06757569
24-5482
Radialis PET Imager for the Assessment of Neuritic Amyloid Plaque BurdenDr. Ur MetserOther
NCT04985604
DAY101-102
Tovorafenib (DAY101) Monotherapy or in Combination With Other Therapies for Patients With Melanoma and Other Solid TumorsDr. Warren MasonOther
Unknown
NCT03368625
17-5689
A Study of Neoadjuvant Stereotactic Radiosurgery for Large Brain MetastasesDr. David ShultzUnknown
 
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To refer a patient to a clinical trial, complete a new patient referral form. Learn more about the Princess Margaret referral process »

For patients: Are you considering taking part in a clinical trial? Learn more about how and why clinical trials are done and what you can expect if you decide to take part in a trial »

https://www.uhn.ca/PrincessMargaret/Education/Continuing_Education_Programs/Pages/continuing_education_programs.aspx
Last reviewed: 2/2/2023
Last modified: 10/31/2023 7:29 AM
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