Arthritis Newsletter September 2020

THANK YOU ...

Dr. Aileen Davis, Senior Scientist at Krembil and a current board member of the Osteoarthritis Research Society International (OARSI), retired on June 30, 2020 after 23 years as a researcher. Over the course of her career, Dr. Davis published more than 257 scientific articles. One of her most notable achievements is helping to bring the GLA:D program to Canada. GLA:D is an evidence-based program developed in Denmark for the treatment and management of osteoarthritic symptoms. Her findings revealed that deploying GLA:D in Canada helped to significantly reduce pain and improve function in Canadians living with hip and knee osteoarthritis. GLA:D is now being offered as routine evidence-based care to individuals with hip and knee osteoarthritis across the country.

On behalf of the Arthritis Program, we would like to thank you, Aileen, for your great contribution to the field.

On August 27, 2020, Cynthia (Cindy) Merey, retired from a long career in the Division of Orthopedic Surgery. Cindy retired from her role as Administrative Coordinator of the Division of Orthopedic Surgery after 41 years at Toronto Western Hospital.
Note from Dr. Christian Veillette – Division Head, Orthopedic Surgery: "We never really thought this day would come as your timeless devotion and dedication to the Division could never come to an end. Even though you are retiring your spirit and kindness will always be with us. You are truly an exceptional person and your tolerance of all of our idiosyncrasies helped keep the Division together all these years. You have been the face of the Division and brought so much comfort and optimism to medical students, residents, fellows, staff and surgeons – always being there to listen and support with compassion. You have made the Division a better place by being in it. Dr. Ogilvie-Harris said it best in his farewell tribute "Your dedication in making us run smoothly is unsurpassed. Through trials and tribulations the call rang out "lets ask Cindy" or "see what Cindy can do". Bricks (like orthopods) need mortar to hold together, and you were instrumental in keeping the pieces in place and functional." Your positive legacy will be long-lasting – teaching us to treat everyone with kindness, compassion and respect always. On behalf of the entire Division we wish you and Andy all the best in your retirement."

On April 30, 2020, Nurse Phyllis McGee retired from a long career in nursing. Nurse McGee graduated from Ryerson University 42 years ago. She has had experience in Pediatric Intensive Care, Pediatric Neurosurgery and Neuro-oncology, Pediatric and Adult Hepatology and finally within the Arthritis Program as part of the Rheumatology team. Phyllis was the Clinical Coordinator, Biologic Surveillance at the TWH Rheumatology Clinic. She skillfully navigated the complex landscape of transitioning of patients to biologic therapies, while providing valuable education and support to those patients.

On behalf of the Arthritis Program and the Division of Rheumatology, we wish you, Phyllis, all the best in your future endeavors.

NEW APPOINTMENTS AND PROMOTIONS

Director of the Hand Program

Dr. Heather Baltzer has transitioned from being interim Director of the Hand Program to being official Director of the Hand Program, for a 5-year term effective July 1, 2020.

New Physician Assistant

Anne Dang joins the Arthritis Program as the newest Orthopaedic Physician Assistant. Anne graduated from McMaster PA Program and brings almost a decade of orthopaedic PA experience, having most recently worked at Joseph Brandt Hospital in Burlington.

NEW RESEARCH INFRASTRUCTURE

Arthritis Program New Metabolomics Facility

The arthritis program is delighted to announce the opening of the metabolomics centre within the Arthritis Program. This centre is currently in the pilot stage and is being created to provide fast, effective metabolomics solutions to the Arthritis Program, Krembil and UHN. We would like to welcome Dr. Nikita Looby, a metabolomics expert, who is joining us from the University of Waterloo. She will be working under the guidance of Dr. Vinod Chandran and Dr. Mohit Kapoor to kick start this metabolomics core facility.

AWARDS, GRANTS AND RECOGNITIONS

CIHR-The Arthritis Society Team Grant in Cannabis Research

Dr. Hance Clarke, Dr. Mohit Kapoor, Dr. Lakshmi Kotra, Dr. Timothy Leroux as PIs along with Co-Investigators including Dr. Anuj Bhatia, Dr. Robert Bonin, Dr. Aileen Davis, Dr. Eleanor Fish, Dr. Andrea Furlan, Dr. Igor Jurisica, Ms. Sarah Miles, Mr. George Tomlinson, Dr. Michael Zywiel and Dr. Jason Rockel secured the CIHR-The Arthritis Society Team Grant in Cannabis Research. The team received the grant for their project “Cannabis-based precision medicine for osteoarthritis therapy” and was ranked #1 in this competition.

Canadian Institutes of Health Research Funding for COVID-19 Research

Dr. Angela M. Cheung, Director of the Osteoporosis Program, along with Dr. Margaret Herridge, secured funding through CIHR's "COVID-19 Rapid Research Funding Opportunity" for their project looking at the effects of COVID-19 on patients up to one year after infection.

Long-Serving Member

Dr. Arthur Bookman, Rheumatologist at TWH, was recently recognized as a long-serving member of TeamUHN. Dr. Bookman has been at UHN for over 40 years.

Lupus Research Alliance Awardee and Associate Professor

Dr. Zahi Touma is now an Associate Professor of medicine in the Division of Rheumatology at the University of Toronto. Dr. Touma is also a rheumatologist in the Division of Rheumatology at Toronto Western Hospital and Mount Sinai Hospital, as well as a clinician scientist at Krembil. Dr. Touma has been awarded a grant from the Lupus Research Alliance for his project “Modeling Cognitive Impairment in Patients with Systemic Lupus Erythematosus.”

Spondyloarthritis Research Consortium of Canada (SPARCC)

Laura Passalent was awarded a one-year seed grant through the Pilot Project Research Program for the project titled "We Got Your Back, version 2.0: Pan-Canadian Implementation and Evaluation of an E-learning Patient Education Program in Axial Spondyloarthritis – A Pilot Study". Laura is an ACPAC physiotherapist and a clinician investigator at Krembil.

Dr. Akihiro Nakamura, a clinical fellow and a PhD candidate supervised by Dr. Nigil Haroon, was awarded a one-year seed grant through the Pilot Project Research Program for the project titled "MIF-mediated Treg Conversion into Th17 Cells in Ankylosing Spondylitis".

Dr. Ashish Jacob Mathew was awarded a one-year seed grant through the Pilot Project Research Program for the project titled "Metabolomic Profiling in Responders and Non-Responders to Tumor Necrosis Factor Inhibitor and Interleukin-17 Inhibitor Therapy in Psoriatic Arthritis". Dr. Mathew is a clinical fellow at the Arthritis Program.

2019-2020 Frederick Banting and Charles Best Canada Graduate Scholarship

Brian Wu, a PhD candidate supervised by Dr. Mohit Kapoor, received the Canadian Institutes of Health Research (CIHR) 2019-2020 Frederick Banting and Charles Best Canada Graduate Scholarships – Doctoral Research Award (CGS-D).

Lupus Foundation of America 2020 Gary S. Gilkeson Career Development Award

Dr. Laura Whittall Garcia, Clinical Fellow working with Drs. Murray Urowitz and Joan Wither, the 2020 Gary S. Gilkeson Career Development Award from the Lupus Foundation of America a two-year grant supporting the professional growth of early career scientists as they establish their studies in lupus research, helping to grow the lupus research field. Laura’s project will measure the blood levels of IFN-alpha and Neutrophil Extracellular Traps (NETs), which induce IFN-1 genes – an inflammatory marker that is typically higher in patients who do not respond to lupus nephritis therapy.

National Psoriasis Foundation of America Early Career Research Grant

Dr. Omar Cruz Correa, a Post-Doctoral Fellow working under the supervision of Dr. Dafna Gladman, received the Early Career Research Grant from the National Psoriasis Foundation of America. Omar’s project will study the difference in genome-wide DNA methylation profiles of psoriasis patients to identify predictive to develop a machine learning classification model capable of predicting converts and non-converters.

National Psoriasis Foundation of America Summer Student Research Grant

Glen Katsnelson, a Medical Student at the University of Toronto working under Dr. Dafna Gladman's supervision, received the National Psoriasis Foundation of America Summer Student Research Grant for project tilted "Minimally Clinically Important Difference in the European QoL-5 Dimensions Questionnaire (EQ5D) in Psoriatic Arthritis: Distinguishing Biologic Treat Patients".

2020 Gina M. Finzi Memorial Student Summer Fellowship Award

Jennifer He, 4th Year, BMSc at Western University working under Dr. Zahi Touma's supervision received the Lupus Foundation of America 2020 Gina M. Finzi Memorial Student Summer Fellowship Award for project titled "Improving the assessment of cognitive function in patients with systemic lupus erythematosus: Insight into intraindividual variability across neuropsychological tests and its association with cognitive impairment".

National Psoriasis Foundation of America Early Career Research Grant

Jacqueline Lai, 4th Year, BMSc, at Western University, working under Dr. Vinod Chandran's supervision received the Canadian Association of Psoriasis Patients Summer Studentship for project titled "Prognosis and Biomarker Studies in Psoriasis and Psoriatic Arthritis".

Two postdoctoral fellows of the Arthritis Program received awards during the 2020 Virtual Krembil Research Day which took place on Aug 11, 2020. Anusha Ratneswaran, a postdoctoral fellow under the supervision of Dr. Mohit Kapoor, won 1st prize for the Poster Presentation Postdoctoral Category. Dr. Kieran Manion, a postdoctoral fellow under the supervision of Dr. Joan Wither, won 1st prize for the Oral Presentation Postdoctoral Category.

RESEARCH DAYS

International Society of Cell and Gene Therapy (ISCT) Annual Meeting

Dr. Sowmya Viswanathan, Scientist at Krembil, chaired the "Mesenchymal Stromal Cells - Full Circle - Basic Research Insights to Clinical Trial Updates" plenary session at the International Society of Cell and Gene Therapy (ISCT) annual meeting. Due to COVID-19 restrictions, the annual meeting took place virtually on May 28-29, 2020.

ONLINE INNOVATION

Arthritis Program Web Seminar Series

The Arthritis Program Web Seminar Series is a medium for live and recorded webinars from world leading experts in the field of bone and joint-related pathologies and rheumatic diseases. The seminar series started on May 19, 2020. So far, this ongoing web seminar series has covered 13 lectures. Click here to watch the latest recorded lectures on the Arthritis Program Research and Education website.

The web seminars will resume on Sept 15, 2020 with some excellent speakers and topics lined up. Stay tuned for further announcements.

Molecular Systems Architecture of Human Knee Osteoarthritis

A collaboration between the Division of Orthopedics and CytoSolve, Inc., a multi-scale molecular systems architecture has been created to provide a comprehensive and integrative molecular systems understanding of human knee osteoarthritis (OA). The architecture is constructed through a supervised bioinformatics process beginning with nearly 20,000 scientific papers curated to a refined set of 5,245 papers from which molecular interactions are extracted. The systems architecture is accessed through an easy-to-use interface to traverse the complexity of knee OA systems biology from tissue to cell to an ensemble of molecular interactions whereby one may discover the particular paper from which an interaction is derived. The systems architecture maintains its currency by enabling the research community to provide feedback that can be reviewed, refereed and incorporated. The architecture provides a framework for developing new educational tools as well as to support research that aims to investigate disease mechanisms, and identify potential therapeutic targets for the treatment of knee OA. Click here to view the knee OA molecular architecture. /p>

New Look for the Arthritis Program Website

Over the past few months, Marsha Alvares, Advanced Physiotherapy Practitioner and Clinical Manager – MSK Bundles, and Suzanne Wice, Public Affairs Advisor and Web Content Lead, with the help of many members of the Arthritis Program, have been working to revamp the Arthritis Program web page. The final changes were published last month.

This is Phase 1 of the update that included the main landing page and changes to the Orthopedic Division to align with the roll out of Bundled Care.

The next phase will include updates to the remaining Divisions within the Arthritis Program. This is a long awaited change and the main driving force was to make it more patient friendly.

Check out the new changes here.

Virtual Care for Ontarians with Low Back Pain during COVID-19

Due to COVID-19, a Virtual Care strategy was required that could be implemented quickly across Ontario’s Low Back Rapid Access Clinics (LB RACs) to ensure Ontarians suffering with back pain could get timely access to high quality safe care. To this end, Dr. Raja Rampersaud, Provincial Clinical Lead for Lower Back Pain Pathway, and spine surgeon along with Marcia Correale, Provincial Practice Lead, spearheaded the development of low back assessments and education tools to support providers with remotely managing patients with new or worsening back pain. A Virtual toolkit was developed with support from UHN’s Arthritis Program ISAEC Operations Team and the Low Back Pain Provider Network across 16 LB RAC regional hubs spanning from Windsor to Thunder Bay, ensuring standardized care is offered and lowering the risk of chronic lower back pain in Ontario. The kit includes how-to videos for both patients and providers. More information can be found here.

NOTABLE PUBLICATIONS

The Epidemiology of Scapholunate Advanced Collapse

GMurphy BD, Nagarajan M, Novak CB, Roy M, McCabe SJ. Hand. January 2020.
Click here for publication.

Effect of vasopressor use on digit survival after replantation and revascularization—A large retrospective cohort study

Retrouvey H, Makerewich JR, Solaja O, Giuliano AM, Niazi AU, Baltzer HL. Microsurgery. January 2020. Click here for publication.

Identifying priorities and developing strategies for building capacity in amputation research in Canada

Hitzig SL, Mayo AL, Kayssi A, Viana R, MacKay C, Devlin M, Dilkas S, Domingo A, Hebert JS, Miller WC, Andrysek J, Azhari F, Baltzer HL, de Mestral C, Dittmer DK, Dudek NL, Grad S, Guilcher SJT, Habra N, Hunter SW, Journeay WS, Katz J, King S, Payne MW, Underwood HA, Zariffa J, Aternali A, Atkinson SL, Brooks SG, Cimino SR, Rios J. Disability and Rehabilitation. February 2020. Click here for publication.

Lipocalin 2 links inflammation and ankylosis in the clinical overlap of inflammatory bowel disease (IBD) and ankylosing spondylitis (AS)

Lin A, Inman RD, Streutker CJ, Zhang Z, Pritzker KPH, Tsui HW, Tsui FWL. Arthritis Research & Therapy. March 2020. Click here for publication.

The lower trapezius transfer: a systematic review of biomechanical data, techniques, and clinical outcomes

Clouette J, Leroux T, Shanmugaraj A, Khan M, Gohal C, Veillette C, Henry P, Paul RA. Journal of Shoulder and Elbow Surgery. March 2020. Click here for publication.

Tumour necrosis factor inhibitor dose reduction for axial spondyloarthritis: A systematic review and meta-analysis of randomized controlled trials

Lawson DO, Eraso M, Mbuagbaw L, Joanes M, Aves T, Leenus A, Omar A, Inman RD. Arthritis Care & Research. March 2020. Click here for publication.

The contribution of age and obesity to the number of painful joint sites in individuals reporting osteoarthritis: a population-based study

Badley EM, Wilfong J, Yip C, Millstone DB, Perruccio AV. Rheumatology (Oxford). April 2020. Click here for publication.

Impact of disease activity on organ damage progression in systemic lupus erythematosus: University of Toronto Lupus Clinic Cohort

PUrowitz MB, Gladman DD, Ibañez D, Su J, Mursleen S, Sayani A, Alfonso J, Terres R, Iczkovitz S. The Journal of Rheumatology. April 2020. Click here for publication.

The Effects of Home Exercise in Older Women With Vertebral Fractures: A Pilot Randomized Controlled Trial

Gibbs JC, McArthur C, Wark JD, Thabane L, Scherer SC, Prasad S, Papaioannou A, Mittmann N, Laprade J, Kim S, Khan A, Kendler DL, Hill KD, Cheung AM, Bleakney R, Ashe MC, Adachi JD, Giangregorio LM. Physical Therapy. April 2020.
Click here for publication.

Prediction of Damage Accrual in Systemic Lupus Erythematosus Using the Systemic Lupus International Collaborating Clinics Frailty Index

Legge A, Kirkland S, Rockwood K, Andreou P, Bae SC, Gordon C, Romero-Diaz J, Sanchez-Guerrero J, Wallace DJ, Bernatsky S, Clarke AE, Merrill JT, Ginzler EM, Fortin PR, Gladman DD, Urowitz MB, Bruce IN, Isenberg DA, Rahman A, Alarcón GS, Petri M, Khamashta MA, Dooley MA, Ramsey-Goldman R, Manzi S, Zoma AA, Aranow C, Mackay M, Ruiz-Irastorza G, Lim SS, Inanc M, van Vollenhoven RF, Jonsen A, Nived O, Ramos-Casals M, Kamen DL, Kalunian KC, Jacobsen S, Peschken CA, Askanase A, Hanly JG. Arthritis & Rheumatology. April 2020. Click here for publication.

Participation in informal caregiving among people with arthritis: Findings from the Canadian Longitudinal Study on Aging

Wilfong JM, Perruccio AV, Millstone DB, Badley EM. Arthritis Care & Research. May 2020. Click here for publication.

Direct and indirect utilities of patients with mild to moderate versus severe carpal tunnel syndrome

Wang AM, Retrouvey H, Krahn M, McCabe SJ, Baltzer HL. Journal of Hand Surgery (European Volume). May 2020. Click here for publication.

A Comparison of 2019 EULAR/ACR SLE Classification Criteria with Two Sets of Earlier SLE Classification Criteria

Petri M, Goldman DW, Alarcón GS, Gordon C, Merrill JT, Fortin PR, Bruce IN, Isenberg D, Wallace D, Nived O, Ramsey-Goldman R, Bae SC, Hanly JG, Sanchez-Guerrero J, Clarke AE, Aranow C, Manzi S, Urowitz M, Gladman DD, Kalunian K, Werth VP, Zoma A, Bernatsky S, Khamashta M, Jacobsen S, Buyon JP, Dooley MA, van Vollenhoven R, Ginzler E, Stoll T, Peschken C, Jorizzo JL, Callen JP, Lim S, Inanç M, Kamen DL, Rahman A, Steinsson K, Franks AG Jr, Magder LS. Arthritis Care & Research (Hoboken). May 2020. Click here for publication.

Incidence of Uveitis in Secukinumab-treated Patients With Ankylosing Spondylitis: Pooled Data Analysis From Three Phase 3 Studies

Deodhar AA, Miceli-Richard C, Baraliakos X, Marzo-Ortega H, Gladman DD, Blanco R, Das Gupta A, Martin R, Safi J Jr, Porter B, Shete A, Rosenbaum JT. ACR Open Rheumatology. May 2020. Click here for publication.

Pathway to biomarker discovery in psoriatic arthritis

Chandran V. Expert Review of Clinical Immunology. May 2020. Click here for publication.

Acute Fifth Metatarsal Tuberosity Fractures: A Systematic Review of Non‐Operative Treatment

Khan S, Axelrod D, Paul R, Catapano M, Stephen D, Henry P, Wasserstein D. PM&R. May 2020. Click here for publication.

Identifying a response for the systemic lupus erythematosus disease activity glucocorticoid index (SLEDAI-2KG)

Touma Z, Gladman DD, Zandy M, Su J, Anderson N, Urowitz MB. Arthritis Care & Research (Hoboken). May 2020. Click here for publication.

Mortality in psoriatic arthritis: Risk, causes of death, predictors for death

Elalouf O, Muntyanu A, Polachek A, Pereira D, Ye JY, Lee KA, Chandran V, Cook RJ, Gladman DD. Seminars in Arthritis and Rheumatism. May 2020. Click here for publication.

Effect of TNF-inhibitor therapy on spinal structural progression in ankylosing spondylitis patients: A systematic review and meta-analysis

Ajrawat P, Touma Z, Sari I, Taheri C, Diaz Martinez JP, Haroon N. International Journal of Rheumatic Diseases. May 2020. Click here for publication.

Challenges in the clinical diagnosis of psoriatic arthritis

Rida MA, Chandran V. Journal of Clinical Immunology. May 2020. Click here for publication.

Secondary Effects of Radiation Therapy to the Hand for Benign Conditions

Steen K, Hayward V, Novak C, Anastakis D, McCabe S. Hand. May 2020. Click here for publication.

Impact of the new American College of Cardiology/American Heart Association definition of hypertension on atherosclerotic vascular events in systemic lupus erythematosus

Tselios K, Gladman DD, Su J, Urowitz M. Annals of the Rheumatic Diseases. May 2020. Click here for publication.

Effect of Autotaxin Inhibition in a Surgically-Induced Mouse Model of Osteoarthritis

Datta P, Gandhi R, Nakamura S, Lively S, Rossomacha E, Potla P, Shestopaloff K, Endisha H, Pastrello C, Jurisica I, Rockel J, Kapoor M. Osteoarthritis and Cartilage. June 2020. Click here for publication.

Effect of Secukinumab on the Different GRAPPA-OMERACT Core Domains in Psoriatic Arthritis: A Pooled Analysis of 2049 Patients

Orbai AM, McInnes IB, Coates LC, Husni ME, Gladman DD, Gossec L, Pricop L, Chambenoit O, Meng X, Mease PJ. The Journal of Rheumatology. June 2020. Click here for publication.

Rapid and sustained improvements in patient-reported signs and symptoms with ixekizumab in biologic-naive and TNF-inadequate responder patients with psoriatic arthritis

Orbai AM, Gladman DD, Goto H, Birt JA, Gellett AM, Lin CY, Kvien TK. Clinical and Experimental Rheumatology. June 2020. Click here for publication.

Cognitive function trajectories are associated with the depressive symptoms trajectories in systemic lupus erythematosus over time

Touma Z, Moghaddam B, Su J, Katz P. Arthritis Care & Research (Hoboken). June 2020. Click here for publication.

Depression in Psoriatic Arthritis: Dimensional Aspects and Link with Systemic Inflammation

Mathew AJ, Chandran V. Rheumatology and Therapy. June 2020. Click here for publication.

Understanding the association between osteoarthritis and social participation: a population-based study

Perruccio AV, Yip C, Power JD, Canizares M, Gignac MAM, Badley EM. Arthritis Care & Research. June 2020. Click here for publication.

Accrual of Atherosclerotic Vascular Events in a Multicenter Inception Systemic Lupus Erythematosus Cohort

Urowitz MB, Gladman DD, Farewell V, Su J, Romero-Diaz J, Bae SC, Fortin PR, Sanchez-Guerrero J, Clarke AE, Bernatsky S, Gordon C, Hanly JG, Wallace DJ, Isenberg DA, Rahman A, Merrill JT, Ginzler E, Alarcón GS, Chatham WW, Petri MA, Bruce IN, Khamashta MA, Aranow C, Dooley MA, Manzi S, Ramsey-Goldman R, Nived O, Jönsen A, Steinsson K, Zoma AA, Ruiz-Irastorza G, Lim SS, Kalunian KC, Ỉnanç M, van Vollenhoven R, Ramos-Casals M, Kamen DL, Jacobsen S, Peschken CA, Askanase A, Stoll T. Arthritis & Rheumatology. June 2020. Click here for publication.

Measurement properties of selected patient-reported outcome measures for use in randomised controlled trials in patients with systemic lupus erythematosus: a systematic review

Strand V, Simon LS, Meara AS, Touma Z. Lupus Science & Medicine. June 2020. Click here for publication.

Liver Abnormalities in Patients with Psoriatic Arthritis

Pakchotanon R, Ye JY, Cook RJ, Chandran V, Gladman DD. The Journal of Rheumatology. June 2020. Click here for publication.

Safety and Efficacy of Tofacitinib in Patients with Active Psoriatic Arthritis: Interim Analysis of OPAL Balance, an Open-Label, Long-Term Extension Study

Nash P, Coates LC, Kivitz AJ, Mease PJ, Gladman DD, Covarrubias-Cobos JA, FitzGerald O, Fleishaker D, Wang C, Wu J, Hsu MA, Menon S, Fallon L, Romero AB, Kanik KS. Rheumatology and Therapy. June 2020. Click here for publication.

Is axial psoriatic arthritis distinct from ankylosing spondylitis with and without concomitant psoriasis?

Feld J, Ye JY, Chandran V, Inman RD, Haroon N, Cook R, Gladman DD. Rheumatology (Oxford). June 2020. Click here for publication.

International league of associations for rheumatology recommendations for the management of psoriatic arthritis in resource-poor settings

Elmamoun M, Eraso M, Anderson M, Maharaj A, Coates L, Chandran V; ILAR-PsA recommendations group, Abogamal A, Adebajo AO, Ajibade A, Ayanlowo O, Azevedo V, Bautista-Molano W, Carneiro S, Goldenstein-Schainberg C, Hernandez-Velasco F, Ima-Edomwonyi U, Lima A, Medina-Rosas J, Mody GM, Narang T, Ortega-Loayza AG, Ranza R, Sharma A, Toloza S, Vega-Espinoza L, Vega-Hinojosa O. Clinical Rheumatology. June 2020. Click here for publication.

Antisense oligonucleotide-based therapies for the treatment of osteoarthritis: Opportunities and roadblocks

Nakamura A, Ali SA, Kapoor M. Bone. June 2020. Click here for publication.

Hydroxychloroquine shortages among patients with systemic lupus erythematosus during the COVID-19 pandemic: experience of the Systemic Lupus International Collaborating Clinics

Mendel A, Bernatsky S, Askanase A, Bae SC, Clarke AE, Costedoat-Chalumeau N, Gladman DD, Gordon C, Hanly J, Jacobsen S, Kalunian K, Mak A, Mosca M, Pons-Estel BA, Ruiz-Irastorza G, Urowitz M, Vinet É. Annals of the Rheumatic Diseases. June 2020. Click here for publication.

Health care utilization and costs for spinal conditions in Ontario, Canada – opportunities for funding high-value care: a retrospective cohort study

Rampersaud YR, Power JD, Perruccio AV, Paterson JM, Veillette C, Coyte PC, Badley EM, Mahomed NN. The Spine Journal. June 2020. Click here for publication.

Influence of psychological factors on patient-reported upper extremity disability

Cheng H, Novak CB, Veillette C, von Schroeder HP. Journal of Hand Surgery (European Volume). July 2020. Click here for publication.

Bisphosphonate use is protective of radiographic knee osteoarthritis progression among those with low disease severity and being non-overweight: data from the Osteoarthritis Initiative

Hayes KN, Giannakeas V, Wong AKO. Journal of Bone and Mineral Research. July 2020. Click here for publication.

Medial Elbow Exposure: An Anatomic Comparison of Five Approaches

Huang AL, Hackl M, Chan AH, Axford DT, Athwal GS, King GJ. Journal of Shoulder and Elbow Surgery. July 2020. Click here for publication.

Sequencing identifies a distinct signature of circulating microRNAs in early radiographic knee osteoarthritis

Ali SA, Gandhi R, Potla P, Keshavarzi S, Espin-Garcia O, Shestopaloff K, Pastrello C, Bethune-Waddell D, Lively S, Perruccio AV, Rampersaud YR, Veillette C, Rockel JS, Jurisica I, Appleton T, Kapoor M. Osteoarthritis & Cartilage. July 2020. Click here for publication.

Trends in Digital Replantation: 10 Years of Experience at a Large Canadian Tertiary Care Center

Solaja O, Retrouvey H, Baltzer H. Plastic Surgery. July 2020. Click here for publication.

Canadian Plastic Surgery Resident Operative Experience in Hand Surgery

Yeung C, Shih JG, Knox AD, Zhygan N, Courtemanche DJ, Fish JS, Brown MH, Anastakis D. The Journal of Hand Surgery. July 2020. Click here for publication.

Outcomes of secondary combined proximal Interphalangeal joint release and zone II flexor tenolysis

Zuo KJ, Saggaf M, von Schroeder HP, Binhammer P. Hand. July 2020. Click here for publication.

Plastic changes in the brain after human hand allotransplantation

Ni Z, McCabe S, Novak C, Baltzer HL, Jegatheeswaran G, Isayama R, Vesia M, Gunraj C, Saha U, Hallett M, Chen R. Neurology. July 2020. Click here for publication.

Discordance between self-reported and performance-based function among knee osteoarthritis surgical patients: Variations by sex and obesity

Wilfong JM, Badley EM, Power JD, Gandhi R, Rampersaud YR, Perruccio AV. Plos One. July 2020. Click here for publication.

TAT-Beclin-1 induces severe synovial hyperplasia and does not protect from injury-induced osteoarthritis in mice

Rockel J, Wu B, Nakamura S, Rossomacha E, Espin-Garcia O, Gandhi R, Kapoor M. Osteoarthritis and Cartilage. July 2020. Click here for publication.

Impact of guselkumab, an interleukin-23 p19 subunit inhibitor, on enthesitis and dactylitis in patients with moderate to severe psoriatic arthritis: results from a randomised, placebo-controlled, phase II study

Mease PJ, Gladman DD, Deodhar A, McGonagle DG, Nash P, Boehncke WH, Gottlieb A, Xu XL, Xu S, Hsia EC, Karyekar CS, Helliwell PS. RMD Open. July 2020. Click here for publication.

Long-Term Safety and Tolerability of Apremilast Versus Placebo in Psoriatic Arthritis: A Pooled Safety Analysis of Three Phase III, Randomized, Controlled Trials

Mease PJ, Gladman DD, Gomez-Reino JJ, Hall S, Kavanaugh A, Lespessailles E, Schett G, Paris M, Delev N, Teng L, Wollenhaupt J. ACR Open Rheumatology. July 2020. Click here for publication.

Propensity Score Methods in Rare Disease. A Demonstration Using Observational Data in Systemic Lupus Erythematosus

Almaghlouth I, Pullenayegum E, Gladman DD, Urowitz MB, Johnson SR. The Journal of Rheumatology. July 2020. Click here for publication.

Sex-Modified Effects of Depression, Low Back Pain, and Comorbidities on Pain After Total Knee Arthroplasty for Osteoarthritis

Perruccio AV, Fitzpatrick J, Power JD, Gandhi R, Rampersaud YR, Mahomed NN, Davey JR, Syed K, Veillette C, Badley EM. Arthritis Care & Research (Hoboken). August 2020. Click here for publication.

MicroRNAs in synovial pathology associated with osteoarthritis

Tavallaee G, Rockel J, Lively S, Kapoor M. Frontiers in Medicine. August 2020. Click here for publication.

The impact of multijoint symptoms on patient-reported disability following surgery for lumbar spine osteoarthritis

Perruccio AV, Power JD, Yip C, Badley EM, Canizares M, Rampersaud YR. The Spine Journal. August 2020. Click here for publication.

Performance of the 2019 EULAR/ACR classification criteria for systemic lupus erythematosus in early disease, across sexes and ethnicities

Johnson SR, Brinks R, Costenbader KH, Daikh D, Mosca M, Ramsey-Goldman R, Smolen JS, Wofsy D, Boumpas DT, Kamen DL, Jayne D, Cervera R, Costedoat-Chalumeau N, Diamond B, Gladman DD, Hahn B, Hiepe F, Jacobsen S, Khanna D, Lerstrøm K, Massarotti E, McCune J, Ruiz-Irastorza G, Sanchez-Guerrero J, Schneider M, Urowitz M, Bertsias G, Hoyer BF, Leuchten N, Tani C, Tedeschi SK, Touma Z, Schmajuk G, Anic B, Assan F, Chan TM, Clarke AE, Crow MK, Czirják L, Doria A, Graninger WB, Halda-Kiss B, Hasni S, Izmirly PM, Jung M, Kumánovics G, Mariette X, Padjen I, Pego-Reigosa JM, Romero-Diaz J, Rúa-Figueroa Í, Seror R, Stummvoll GH, Tanaka Y, Tektonidou MG, Vasconcelos C, Vital EM, Wallace DJ, Yavuz S, Meroni PL, Fritzler MJ, Naden R, Dörner T, Aringer M. Annals of the Rheumatic Diseases. August 2020. Click here for publication.

The skin microbiome in psoriatic disease: A systematic review and critical appraisal

Yerushalmi M, Elalouf O, Anderson M, Chandran V. Journal of Translational Autoimmunity. August 2020. Click here for publication.

Performance of composite measures used in a trial of etanercept and methotrexate as monotherapy or in combination in psoriatic arthritis

Coates LC, Merola JF, Mease PJ, Ogdie A, Gladman DD, Strand V, van Mens LJJ, Liu L, Yen PK, Collier DH, Kricorian G, Chung JB, Helliwell PS. Rheumatology (Oxford). August 2020. Click here for publication.

The association between synovial fluid serine proteinase activity and response to intra-articular corticosteroid injection in psoriatic arthritis

Abji F, Ye JY, Cook RJ, Oikonomopoulou K, Chandran V. Clinical Rheumatology. August 2020. Click here for publication.

Cancer risk in a large inception SLE cohort: Effects of demographics, smoking, and medications

Bernatsky S, Ramsey-Goldman R, Urowitz MB, Hanly JG, Gordon C, Petri MA, Ginzler EM, Wallace DJ, Bae SC, Romero-Diaz J, Dooley MA, Peschken CA, Isenberg DA, Rahman A, Manzi S, Jacobsen S, Lim SS, van Vollenhoven R, Nived O, Kamen DL, Aranow C, Ruiz-Irastorza G, Sanchez-Guerrero J, Gladman DD, Fortin PR, Alarcón GS, Merrill JT, Kalunian KC, Ramos-Casals M, Steinsson K, Zoma A, Askanase A, Khamashta MA, Bruce I, Inanc M, Clarke AE. Arthritis Care & Research (Hoboken). August 2020. Click here for publication.

Case Report of Refractory Psoriatic Arthritis Achieving Remission Using Nigella sativa (Black Seed Oil) Extract

Rida MA, Gladman DD. The Journal of Rheumatology. August 2020. Click here for publication.

Recommendations for patients with complex nerve injuries during the COVID-19 pandemic

Chapman KM, Berger MJ, Doherty C, Anastakis DJ, Baltzer HL, Boyd KU, Bristol SG, Byers B, Chan KM, Cunningham CJ, Davidge KM. The Canadian journal of neurological sciences. August 2020. Click here for publication.

Cost-Effectiveness Analysis of Motion Preserving Surgeries for Wrist Arthritis

Retrouvey H, Sander B, von Schroeder HP, Binhammer P, Baltzer HL. Plastic and Reconstructive Surgery. August 2020. Click here for publication.

Bilateral Preiser Disease in a Patient with Sickle Cell Anemia

Catapano J, Overduin OO, von Schroeder HP. Journal of Hand and Microsurgery. August 2020. Click here for publication.

Advanced Chronic Kidney Disease in Lupus Nephritis: Is Dialysis Inevitable?

Tselios K, Gladman DD, Su J, Urowitz MB. The Journal of Rheumatology. September 2020. Click here for publication.

Atopic Dermatitis and Bone Health: A Systematic Review

Mukovozov IM, Morra DE, Giustini D, Tadrous M, Cheung AM, Drucker AM. The Journal of the European Academy of Dermatology and Venereology. August 2020. Click here for publication.

Exploring Fear of Falling and Exercise Self-Efficacy in Older Women With Vertebral Fractures

Ponzano M, Gibbs JC, Adachi JD, Ashe MC, Cheung AM, Hill KD, Kendler D, Khan AA, McArthur C, Papaioannou A, Thabane L, Wark JD, Giangregorio LM. Journal of Aging and Physical Activity. August 2020. Click here for publication.

Vertebral Fractures: Which Radiological Criteria Are Better Associated With the Clinical Course of Osteoporosis?

Lentle BC, Berger C, Brown JP, Probyn L, Langsetmo L, Hammond I, Hu J, Leslie WD, Prior JC, Hanley DA, Adachi JD, Josse RG, Cheung AM, Kaiser SM, Towheed T, Kovacs CS, Wong AKO, Goltzman D. The Canadian Association of Radiologists Journal. August 2020. Click here for publication.